Endocrine Abstracts

Introduction: Obesity is a multifactorial disease associated with numerous comorbidities. Bariatric surgery is postulated as an effective tool in weight loss and improves associated pathologies. The aim of this study was to evaluate and compare the safety and the effects on major comorbidities associated with morbid obesity of gastric bypass (GBP) and sleeve gastrectomy (SG) 2 years after intervention.Methods: Cohort study with intrasubject measures (bef...

Introduction: Patients with large non-functioning pituitary macroadenomas often have symptoms due to varying degree of hypopituitarism and/or mass effect on visual structures, while presentation with hydrocephalus is extremely uncommon.Case report: We describe an 82-year-old man who was referred to the Neurology department of our hospital because of rapidly progressive memory loss. The patient was in good health until ten weeks earlier, when he insidious...

Fibrosis represents a major health concern and presently has no successful treatment. Chronic liver fibrosis leads to portal hypertension, cirrhosis, hepatocellular carcinoma and liver failure. Transforming growth factor β (TGFβ), the main profibrogenic factor, mediates its actions mainly through activation of Smad transcription factors. We have previously observed a cross-talk between the thyroid hormone receptors (TRs) and the TGFβ pathway by which the thyroid...

Introduction: Hypothyroidism (hT) is a very common disease that can affect inpatients prognosis. We analysed the clinical profile of patients with hT admitted to Internal Medicine using a large clinical-administrative database.Methods: A descriptive analysis based on the minimum-data-set database of the Spanish National health System of patients who were discharged from the services of Internal Medicine with the diagnoses of hT during 2005–2012 was ...

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development/progression of retinopathy in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 h and subclinical h...

Introduction: The objective is to evaluate the relationship between early blood pressure alterations (detected by ambulatory blood pressure monitoring (abpm)) and the development of microalbuminuria and arterial hypertension in patients with type 1 diabetes clinically normotensive.Methods: We designed a prospective observational study of 85 patients, clinically normotensive and without microalbuminuria, monitored over 7 years. Abpm was performed over 24 ...

Introduction: The objective is to evaluate the relationship between precocious subclinical hypertension and inflammatory and endothelial dysfunction markers in normotensive and normoalbuminuric patients with type 1 diabetes.Methods: We designed an observational transversal study of 85 patients, clinically normotensive and without microalbuminuria. Ambulatory blood pressure monitoring (abpm) was performed over 24 h and subclinical hypertension was conside...

Introduction: Postprandial hypoglucaemia with hyperinsulinism after laparoscopic gastric bypass is an uncommon complication with an estimated prevalence of 0.2%. Its treatment includes acarbose, diazoxide, somatostatin and GLP-1 analogues or calcium channel blockers in case a strict diet does not work.Case report: A 42-year-old woman with history of gastric bypass in 2005 due to severe obesity (preoperative weight 150 kg) attended our clinic 3 years afte...

Introduction: Currently, there are few data on long-term effects of bariatric surgery. We present the results of 5-year follow-up of a cohort of patients with gastric bypass surgery (GBP).Objectives: i) To determine the prevalence of major comorbidities of morbid obese; ii) to evaluate the gastric bypass effect on this comorbidities, and 10-year estimated cardiovascular risk after 5-year follow-up; and iii) to assess the impact of bariatric surgery on th...

Introduction: The main indications for the somatostatin analogues (SST-A) are acromegalies and/or neuroendocrine tumors. They can increase fecal fats, which could lead to the loss of fat soluble vitamins. There are few published studies showing the effects of the long-term use.Methods: Retrospective study of patients with SST-A indicated from our endocrinology department in the last 10 years. We analysed indications and different epidemiological, clinica...